Argireline vs GHK (Basic)
A side-by-side research comparison of Argireline and GHK (Basic) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Argireline | GHK (Basic) |
|---|---|---|
| Full name | Argireline (Acetyl Hexapeptide-3) | GHK (Glycyl-L-Histidyl-L-Lysine, Copper-Free) |
| Category | Skin & Anti-Aging | Skin & Anti-Aging |
| Status | Research compound | Cosmetic research peptide |
| Mechanism | Competes with SNAP-25 for position in SNARE complex, partially inhibiting vesicle docking and neurotransmitter release, reducing muscle contraction intensity. | GHK is a matrikine signal peptide that resets gene expression toward tissue repair, stimulating collagen, elastin, and glycosaminoglycan synthesis and modulating antioxidant and anti-inflammatory pathways. It readily binds copper to become GHK-Cu in situ. |
| Molecular weight | 889 Da | 340.4 Da |
| Half-life | 8-12 hours (topical) | Short (peptide) |
| Bioavailability | Moderate (topical) | Topical (local); injectable (research) |
| Typical dose | 5-10% solution | Topical serum (~1-3 mg/mL) |
| Frequency | 2x daily | 1-2x daily |
| Route | Topical | Topical |
Argireline reported benefits
- Reduces expression wrinkles up to 30%
- Non-invasive Botox alternative
- Prevents new wrinkle formation
- No muscle paralysis
- Stackable with other peptides
GHK (Basic) reported benefits
- Skin remodeling and repair signaling
- Stimulates collagen and elastin
- Antioxidant and anti-inflammatory
- Supports wound healing
- Improves skin firmness
Related comparisons
Research and educational reference only. Not medical advice.