DMT vs DXM
A side-by-side research comparison of DMT and DXM across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | DMT | DXM |
|---|---|---|
| Full name | N,N-Dimethyltryptamine | Dextromethorphan |
| Category | Psychedelics | Psychedelics |
| Status | Schedule I (research compound) | Over-the-counter cough suppressant (psychedelic at high doses) |
| Mechanism | Activates serotonin 5-HT2A receptors, producing vivid changes in perception. When taken orally in ayahuasca, an MAO inhibitor is needed so it is not broken down too quickly. | At high doses it blocks NMDA glutamate receptors, producing dissociation similar to ketamine. |
| Molecular weight | 188.27 g/mol | 271.40 g/mol |
| Half-life | ~10-15 minutes | ~3-6 hours |
| Bioavailability | Inhaled/injected (very short); oral only with an MAO inhibitor | Oral |
| Typical dose | Controlled dosing in clinical studies | Varies by individual and setting |
| Frequency | One to a few supervised sessions | Occasional |
| Route | Inhalation or IV in research; oral as ayahuasca | Oral |
DMT reported benefits
- Studied for depression
- Very short experience aids research design
- Used to study consciousness
- Long traditional use as ayahuasca
DXM reported benefits
- Widely studied cough medicine
- Dissociative effects at high doses
- Included for awareness
- Researched for mood (as a combo drug)
Related comparisons
Research and educational reference only. Not medical advice.