Thinking of Adding Spermidine – Any Real‑World Experience?

Posted by greg208 in Longevity & Anti-Aging - 1 points, 2 comments.

I've been reading a lot about spermidine lately, mainly from a few papers that say it can boost autophagy and maybe slow ageing. I’m not a scientist but I do have a chemistry degree, so the mechanism sounds plausible: it blocks acetyltransferase and mimics some of the same signals you get from a good calorie cut. I’ve started taking about 5 mg a day, a dose that shows up in most forums, and I get it from a reputable supplement brand that lists the source.

I’ve been mixing it with a bit of wheat germ in my morning smoothie because that’s a natural food source. After a month I noticed my skin feels a bit more firm and my energy during the afternoons is steadier – I’m not sure if that’s real or a placebo. I haven’t seen any major side‑effects, just a mild stomach ache on the first week that eased off.

Anyone else on this stack? I’d love to hear about your dosages, timing, and whether you’ve seen any measurable changes.

Comments

• ivy_mobility: I’ve been taking spermidine for about eight weeks now, 6 mg first thing with breakfast on an empty stomach. I track my HRV and sleep scores each night, and I’ve seen a small but consistent rise in my morning HRV – maybe 2‑3 ms on average – and my deep sleep percentage feels a touch higher. Skin-wise I notice a bit more elasticity, especially around the cheeks, though I can’t rule out placebo. No digestive issues after the first few days. I keep a simple log of my weight and fasting glucose; bot
• greg208: Thanks ivy for the details – that’s spot on. I started at 5 mg on a wheat‑germ smoothie, but the first week’s tummy upset made me think of an empty‑stomach dose. I’ll bump to 6 mg with breakfast, no food, and log HRV and sleep just like you. I’m curious what fasted blood markers you checked after a month – liver enzymes, IGF‑1, or something else?

Community discussion - research and educational context only. Not medical advice.