Rapamycin weekly dose: my 4‑week run and skin results

Posted by hank_m in Longevity & Anti-Aging - 5 points, 4 comments.

Tbh i started a simple 3 mg rapamycin pulse once a week for four weeks, adding 200 mg coq10 daily to keep my mitochondria happy, and i’ve been keeping a quick log of how I feel each day. The first week i noticed a subtle lift in my energy, especially after a late night of editing, and sleep quality was smoother, waking up no longer stuck in that half‑awake state. Skin-wise i saw a slight brightening and a reduction in the fine lines that usually pop up around my eyes; not a dramatic glow‑up but noticeable to my own eye.

No mouth sores or GI upset so far, which is good, and the gym soreness after a heavy lift was lighter than normal – i think that might be the autophagy hit. I keep a caffeine log too, because i’m wondering if the rapa is cutting down my need for that pre‑workout buzz. Anyone else combining it with coq10 or testing a 6‑week cycle? What side‑effects have you seen after a month?

Comments

• ivy_mobility: I’ve done a similar 4‑week pulse at 2‑3 mg weekly and got a comparable lift in HRV early on. The skin brightening you saw is something I’ve noticed too, though it’s subtle – I think it’s more a reduction in oxidative stress than a real resurfacing. I didn’t take coq‑10, but I’ve added 100 mg a day and seen less evening fatigue. No GI upset and only mild muscle soreness left. Curiously, my caffeine intake dropped by about 30 mg on the days I took rapa. Any others noticing a similar caffeine dip?
• hank_m: I actually haven’t been careful with caffeine logs, so that 30 mg drop is a new eye‑opener for me, tbh i’ll start measuring it this week – maybe it’s the same as the HRV lift you saw, or maybe just a coincidence, but it feels right – and i’ll try the 100 mg coq10 you mentioned, still on 3 mg weekly; curious if that changes my evening knock‑back the way it did for you, any other tweaks you added?
• kayla_s: I haven’t really seen a caffeine dip when I switch to rapamycin, but I usually keep my coffee habit unchanged. Maybe it’s about timing, if you drink earlier that day, the effects could fade by the next dose. What’s your usual routine around caffeine on injection days?
• hank_m: Tbh i’ve been keeping coffee the same on the injection day, like a cup at 7am then another at 2pm, and i still feel the same buzz around the workout, but i don’t notice a dip right before the 3mg dose, which is usually around lunch. Sweet as, i guess the timing makes it feel steadier. What’s your usual coffee window on the injection day, and doSom mornings feel more jittery?

Community discussion - research and educational context only. Not medical advice.