Rapamycin 3mg Weekly – My First Week Experience and Questions

Posted by greg208 in Longevity & Anti-Aging - 1 points, 2 comments.

I just started a 3mg weekly rapamycin prescription through a telemedicine longevity clinic. I’m not a chemist on the cutting edge, just a retired firefighter with a bachelor’s in chemistry, so I’m looking for plain talk from people who have been down this road. For me the first week was fine apart from a bitter metallic taste that stuck in my mouth and a couple of mild mouth sores after the injection.

I’ve heard that those are common and usually go away. I also noted that my sleep felt a bit lighter – I woke up earlier but felt less groggy, which is a nice change after my shift‑style training routine. _chip: I’m thinking of adding a daily spermidine supplement to help with the autophagy angle – does anyone know if the two stack safely?

I’m also curious about how long you wait between rapamycin and other immune‑modulating agents, since I’ve been on low‑dose metformin. Anything to point me in the right direction would be appreciated.

Comments

• tinkerer792: I’ve got the same metallic aftertaste and a couple of mouth sores after my first dose, so that tracks with what the literature says about mucositis as a common early side effect of rapamycin, usually it eases in a few weeks. I’ve read a few papers that show spermidine doesn’t have obvious pharmacodynamic clashes with rapamycin, but the data are limited; there’s no large safety study yet, so I’d start with a low dose and watch for any new GI upset or changes in sleep. As for metformin, most repor
• greg208: Thanks for the match‑up on the metallic taste and mouth sores – that bit rings true for me too. I’ll start spermidine at 0.5‑mg daily and boost slowly, watching for any GI upset or new sleep changes as you suggested. About metformin – do you think I should wait a day or two after the rapamycin injection before taking it?

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