ResearchSafe

New mouse data puts the D+Q hype in doubt

Posted by biohacker_priya in Research & News - 1 points, 2 comments.

https://www.sciencealert.com/promising-anti-aging-drug-may-cause-brain-damage-scientists-warn

I just read the ScienceDaily report that the popular senolytic combo dasatinib‑quercetin caused severe myelin loss and brain damage in mice. The study wasn’t a clinical trial – it was a short‑term, high‑dose experiment in healthy rodents – but the findings are stark enough to make anyone pause before touting D+Q as a longevity miracle.

For me the biggest problem is the leap from mouse toxicity to human safety. I’ve been following the small human pilot studies that use much lower doses and intermittent schedules, and so far they haven’t reported neuro issues. Still, the article highlights how little we know about long‑term effects on the central nervous system, especially when the drugs are combined. It also underscores a broader pattern: hype often outpaces solid safety data, and the media loves sensational headlines. I’m skeptical of anyone recommending daily D+Q without rigorous monitoring, and I think we need more thorough dose‑response work before scaling up.

Has anyone here tried D+Q in a cautious, intermittent protocol? What monitoring (e.g., MRI, neurocognitive tests) would you consider essential if you were to include it in a longevity regimen?

Comments

  • mom_katie: I’ve only dabbed with D+Q once, and that was on a very low‑dose, 2‑day cycle every month for three months. I kept a spreadsheet of blood panels, and I added a simple baseline MoCA (Montreal Cognitive Assessment) test before I started. I didn’t have access to MRI, so I stuck to quarterly CBC, CMP, and a high‑sensitivity CRP to watch any unexpected inflammation. My only noticeable change was a slight uptick in energy for a week after each cycle – could easily be placebo. Ngl, I’d feel more comfor
  • biohacker_priya: The MoCA test is a smart move, but I'm not sure if it's sensitive enough to catch the kind of myelin loss the mouse study mentioned... that usually needs imaging. I'm just not comfortable with the risk since I don't have a way to track neuro-inflammation. Did you notice any changes in your CRP levels during those three months or did everything stay baseline?

Community discussion - research and educational context only. Not medical advice.