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trying low‑dose rapamycin once a week – any thoughts on sleep and skin?

Posted by sleep_nina in Longevity & Anti-Aging - 1 points, 2 comments.

honestly i’ve been curious about the whole mTOR thing, so a few weeks ago i started a low‑dose rapamycin protocol – 4 mg once a week, just the same schedule i saw on the telemedicine sites. i’m not a doctor, just a nutrition grad who likes reading the latest longevity studies, so i’m keeping it simple and watching how i feel.

the first couple of doses i felt a bit of mild stomach upset, but that cleared up quick. what i really noticed was a subtle change in my sleep. i tend to wake up a few times middle of the night, but after the second week i slept a bit deeper and didn’t feel that groggy in the morning. i also swear my skin looked a tad smoother – kind of a “well‑hydrated” glow, though i can’t tell if it’s just the cooler weather.

i’m still on the weekly schedule, not mixing with anything else yet. i’ve been checking my blood lipids a month out because i read it can bump them up. anyone else on a similar rapamycin routine? any tips on managing the occasional mouth sore or tweaking the dose for better sleep? thanks in advance.

Comments

  • sauna_tinkerer: I am very curious about this. I think the skin glow you mentioned is INTERESTING, because I have read that mTOR inhibition can help with autophagy, which maybe makes skin look better. For me, I tried a similar weekly dose last year, but anecdotally I felt a bit too tired for my training. I felt like my recovery was a little slow, so I had to be careful with timing. About the mouth sores, I heard some people use a rinse or just stay very hydrated. Do you think the deeper sleep is real, or maybe
  • sasha_v: i think deeper sleep was real for me – I noticed less tossing even before I read any articles, so maybe it’s just mtor effect on circadian rhythm. i did try a simple saline rinse and drank more water, that helped a little with the mild mouth dryness. fwiw, timing my dose after heavy training seemed to avoid the sluggish feeling. 💤

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