New NR Study Shows Modest NAD+ Boost – Worth the Hype or Just a Trend?

Posted by weekend_experiment in Research & News - 1 points, 0 comments.

com/cell-metabolism/fulltext/S1550-4131(23)00234-5) where they gave healthy men 500 mg twice daily for 12 weeks and measured whole‑blood NAD+ levels. The paper reports a roughly 30 % increase, and they note slight improvements in insulin sensitivity, but the primary outcomes weren’t statistically significant. For me, the numbers feel underwhelming – I’ve been taking 300 mg of NR daily for a few months and haven’t noticed any clear change in energy or recovery, other than maybe a steadier mood on heavy training days, but that could be placebo.

The safety profile still looks solid, which is reassuring if you want to experiment, but I wonder if the modest NAD+ rise actually translates to any real functional benefit, especially compared to diet or exercise. Has anyone else felt a tangible difference, or are we just chasing a marginal lab marker?

Community discussion - research and educational context only. Not medical advice.