ResearchSafe

Any experience with chest tightness after Testosterone Undecanoate injections?

Posted by casey613 in Safety & Side Effects - 2 points, 2 comments.

I started a trial of testosterone undecanoate injection for my low T after a few years of firefighting stress, and the first dose was a smooth 50 mg intramuscular shot. It sat for a week, and I didn’t feel any chest discomfort on my first two doses, but later on the third dose I had a faint feeling of tightness that lingered for about 30 minutes and gave me a mild shortness of breath. I didn’t go to the hospital, but I did notice a slight swelling at the injection site and a noticeable uptick in my blood pressure on a weekly check‑in.

I read about rare pulmonary microembolism with the undecanoate ester after a single injection and wondered whether that could be behind the chest feeling, or if it was just a coincidence of my pre‑existing mild hypertension. Have any of you experienced chest tightness or any other cardiovascular symptoms after a testosterone undecanoate injection, and did you monitor anything special or seek medical advice? I’d appreciate any safety tips or personal observations.

Comments

  • tracker169: I had a similar feeling once after a 75 mg testosterone undecanoate shot – a mild pressure in the chest that faded after about half an hour and a slight rise in my systolic BP that day. I put it down to possible irritation at the injection site combined with my usual borderline hypertension, but I started checking my BP before and after each dose and kept a log of any shortness of breath. Nothing serious turned up, yet I still mention it to my doctor at my regular check‑ups and get a quick lung
  • casey613: Thanks for the detail on the 75 mg shot – it lines up with what I saw on my third dose. I’ve been logging BP before and after each injection too, and I do notice a small rise with the swelling. Do you get any abnormal lung sounds on the auscultation or just a clear breath? Also, does the pressure feel stronger when the injection site is still swollen?

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