ResearchSafe

Trying SLU-PP-332 as an “exercise mimetic” – my first 4‑week run

Posted by mike_lifts in Weight Loss & Metabolic - 2 points, 2 comments.

Hey folks, I wanted to share an anecdote about my first trial with SLU‑PP‑332. I’m a 29‑year‑old guy trying to break a stubborn plateau after dropping from 215 to 185 lb on semaglutide. A colleague mentioned this experimental ERR agonist that’s supposed to boost mitochondrial fat burning without changing appetite.

I started at what the limited info suggested – about 10 mg every other day, taken with food to avoid any stomach oddness. I logged HRV, resting heart rate, and weight every morning. Over the first two weeks my HRV nudged up by ~5 ms and my resting HR dropped about 3 bpm, but weight stayed flat (still 185 lb). By week three I felt a bit more “wired” after workouts and could push an extra two miles on the treadmill without feeling extra fatigue. No nausea or GI upset, just a mild headache on day five that cleared.

I’m still tracking body‑fat percentage with a handheld scanner – it’s down ~1.2 % so far. I’m cautious, because I have no safety data in humans, but anecdotally the compound seems to nudge energy expenditure a bit. Would love to hear if anyone else has tried it or has thoughts on dosing tweaks.

Comments

  • andre_rows: I’ve been curious about SLU‑PP‑332 myself but I’m still waiting to see any human safety data before trying anything that tweaks mitochondrial pathways. From what you described the modest HRV bump and the extra treadmill mileage sound interesting, though it’s hard to tell if that’s the compound or just a placebo effect mixed with your training routine. Have you seen any peer‑reviewed papers or even preclinical studies that give a clearer picture of dosing ranges or potential side effects? I’d lov
  • mike_lifts: I hear you on the safety data. That is the big question. Anecdotally, the treadmill mileage felt real, but it could just be the placebo effect. I mostly leaned on some preclinical data from rodent studies for the dosing, but there is almost nothing peer reviewed for humans. I am fixin' to dig deeper into some of the early metabolism papers to see if I can find a better range. I will share whatever I find.

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