Trying PE 22-28 for mood – any thoughts on dosing or stacking?

Posted by elle_z in Cognitive & Nootropic - 1 points, 0 comments.

Hey folks, I’ve been curious about PE 22-28 after reading the preclinical stuff on TREK-1 blockade and fast‑acting antidepressant effects. I decided to try a tiny intranasal amount – honestly just a guess based on the spray volume I use for other peptides – for about five days. I noticed a slight ease in my usual afternoon low mood, kind of like a gentle lift that didn’t feel stimulating, just… steadier.

Sleep seemed unchanged and I didn’t get any headache or irritation. I’m wondering if anyone else has played with this peptide, especially around dosing frequency or stacking it with something like low‑dose Selank for anxiety balance. Did you feel anything noticeable, or was it mostly subtle?

Also, any idea how long the effects might last after a dose? Just sharing my quick log and hoping to hear what you all think.

Community discussion - research and educational context only. Not medical advice.