Trying spermidine for autophagy – any tips on timing with workouts?

Posted by megan302 in Longevity & Anti-Aging - 4 points, 0 comments.

I’ve been taking spermidine powder at about 2 mg each morning with my coffee for the past three weeks. I’m a retired firefighter who now does some part‑time physical therapy work, so i’m often on my feet and doing light strength sessions. I’ve noticed that my usual afternoon stiffness after a clinic day seems a bit lighter, and i recover faster from my own bodyweight circuits, though i know that could just be placebo or the extra hydration i’ve been doing.

I’m curious if others find it better to take spermidine on an empty stomach or with a meal, and whether timing it closer to a workout changes anything. I’ve read that it mimics calorie restriction signaling, so i wonder if taking it after a fasted walk might boost the autophagy signal more. Any personal experiences or things you’ve watched for would be appreciated. Thanks for the help.

Community discussion - research and educational context only. Not medical advice.