Mild nausea on NR, has anyone else seen stomach upset?

Posted by tiredmira in Safety & Side Effects - 2 points, 0 comments.

I started taking nicotinamide riboside about three weeks ago to see if it would help with my energy levels during long clinic days. I began with 300 mg in the morning with breakfast and felt fine for the first week. Then I bumped the dose to 500 mg split into two capsules, one with breakfast and one with lunch.

Around day ten I noticed a mild queasy feeling in my stomach about an hour after the morning dose, sometimes accompanied by a little bloating. It wasn’t severe enough to stop me from working, but it was noticeable and made me skip the second dose on a couple of days. I’ve kept my diet and hydration pretty consistent, so I’m wondering if the NR itself could be the trigger or if it’s just a coincidence.

Has anyone else experienced similar GI upset at higher doses, or does it tend to fade with continued use? I’m thinking of dropping back to 300 mg and seeing if the feeling goes away before trying to go up again.

Community discussion - research and educational context only. Not medical advice.