"Mazdutide vs tirz, anyone compared the two directly?"

Posted by tiredmira in Weight Loss & Metabolic - 1 points, 0 comments.

"I did 4 months on tirz last year, dropped around 35 lbs and the appetite suppression was honestly life changing for me. Got off it for a break and my weight has been creeping back up, like 8 lbs in 2 months, mostly in my midsection it feels like 😅

So now I'm looking at mazdutide as a restart option. The dual GLP-1 plus glucagon action is interesting to me, especially the liver fat piece since my last DEXA showed some visceral fat I wanna target. From the profile it looks like the weight loss numbers can match tirz, maybe even go a bit higher.

Has anyone here actually gone from tirz to mazdutide and can speak to how they compare in real life? I'm specifically curious about the day to day appetite effect, energy levels, and whether the GI sides hit harder on the glucagon side. Also wondering if anyone noticed anything different in body composition, since mazdutide seems to lean more into the fat oxidation angle.

If you did make the switch, did you start at the same low dose or go lower to see how your body reacted? My plan is to titrate slow either way 🥗

Community discussion - research and educational context only. Not medical advice.