Starting spermidine, anyone actually notice autophagy effects?

Posted by coastaldiego in Longevity & Anti-Aging - 2 points, 4 comments.

Kinda new to all this stuff so bear with me 🕰️ been reading up on longevity stuff for a while and spermidine keeps coming up because it supposedly flips on autophagy, which i guess is your cells cleaning out broken junk. Im 40 next year and honestly the appeal is just feeling like im doing something proactive instead of waiting to fall apart.

Ive been taking NMN for like 6 months and the energy stuff seems real, or at least i feel less wiped after work. But autophagy is a different angle and i want to understand it before i throw another thing in the mix. Wheat germ has it naturally but the doses in the studies look way higher than what id get from food.

So for anyone whos tried it, did you actually notice anything or is it the kind of thing where you just hope its working in the background? Fwiw im not chasing any specific result, more curious if people feel different or if its the kind of supplement that just shows up on bloodwork. Also is there a reason to stack it with rapamycin or are they doing the same job?

Comments

• greg208: Solid post and honestly the autophagy question is one i kept getting hung up on too when i started looking into all this. For me on spermidine powder, nothing dramatic at all, i cant say i "felt" autophagy happening because lets be real nobody actually does, its a cellular process not a mood lift. What i did seem to notice was better sleep depth after a few weeks and slightly easier recovery between training days but it could easily be placebo im not gonna lie. On the rapamycin question, theyre
• coastaldiego: Yeah the "cant feel it" part is kinda where i get stuck too lol. Like with NMN i at least noticed something with energy but if autophagy is silent then how do you even know its doing anything. The sleep and recovery stuff is interesting though, i havent been tracking sleep specifically but maybe i should start. Fwiw i wasnt even thinking about rapamycin yet honestly, feel like i gotta understand the basics before i jump to the prescription stuff. Is spermidine something you cycle or do you just
• tiredmira: Yeah exactly, you can't really feel autophagy at all. I tracked HRV and sleep for a few months on spermidine and honestly the numbers were pretty flat for me too, maybe a tiny uptick in deep sleep but nothing I'd bet money on 😅
• coastaldiego: Yeah that tracks with what i was starting to think. I dont have an oura ring or anything fancy but i was wondering if people who actually measure stuff see any signal at all. Tiny uptick in deep sleep is more than i expected honestly. Were you on a specific dose or just eating wheat germ?

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