Anyone layering GHK-Cu topically with oral BPC-157 for a stubborn Achilles insertion?

Question

Chasing a cranky Achilles insertion issue for going on 5 months now. Ngl I'm getting tired of it. I've been on oral BPC-157 arginate for a while and it helped a lot with the achy baseline but I still feel that sharp pinch first thing in the morning and after long efforts. Started reading more about GHK-Cu and the angiogenesis and collagen signaling angle got me curious. Thinking about adding a topical copper peptide serum once a day at night, applied right to the tendon, and keeping oral BPC-157 going morning and night. Not stacking them at the same minute, just spacing it out. Curious if anyone here has actually run both together and what the timing looked like for you. Also wondering if it makes sense to keep using voltaren gel for flare days or if that interferes with whatever the GHK-Cu is trying to do at the local tissue level. Not looking for a protocol, just want to hear what people have actually tried and what stuck.

tiredmira · Accepted Answer

I feel you on the 5 month thing, Achilles stuff just drags. I never stacked GHK-Cu with BPC but I did run a copper peptide serum solo for about 6 weeks on a cranky patellar tendon and I honestly couldn't tell if it did much. The morning pinch was the last thing to fade for me too, basically everything else calmed down but that first step ouch hung around. For voltaren, I was told by someone in my circle to leave a gap between the two since the gel is doing its anti-inflammatory thing at the surface and you probably don't want to slather peptides over it right away. Maybe an hour or so. Not sure if there's real data on the interaction tbh. Have you looked at heel raise progressions at all? That piece did more for me than anything I put on the skin 😅

fasted_scientist · Answer

Mmm the patellar tendon bit is interesting though, 6 weeks and you couldn't tell either way. That's a decent trial window and GHK-Cu has proper collagen remodelling studies behind it, so either you're a non-responder which happens or the dose/concentration in the serum was too weak to matter. The voltaren gap makes sense on paper, ngl. You're basically asking the skin to do two opposing jobs at once if you pile peptides over an anti-inflammatory. An hour buffer feels sensible. Were you using the serum morning or night, and was it a standard 2% or something weaker?

grinder265 · Answer

Yeah I'm a bit confused about the patellar tendon reference, that wasn't me. Might be mixing threads with someone else lol. But to your actual question: I was doing night only, right before bed, applied after the skin had a minute to dry from a shower. Concentration was a standard 2% serum, nothing custom. I never really tested morning vs split dosing so I can't speak to that. I probably should have at this point. The buffer on voltaren tracks, that's basically what I was leaning toward. One hour felt like enough runway for the tissue to clear before layering something else on. Appreciate you laying out the logic on it. Gives me more confidence to just pick one and commit to the timing rather than second-guessing it every day.

grinder265 · Answer

Yeah that morning pinch is the WORST, it's like the tendon reminding you it still hates you every time you swing your legs out of bed. Ngl hearing your patellar story makes me less hyped about the copper peptide going solo but I'll still try it layered with the BPC since I'm already responding to that one. The voltaren gap thing makes sense, I've been kinda doing that by accident already because I usually do the gel midday when it flares and copper peptide at night before bed. So they're already separated by a few hours without me overthinking it. Thanks for that, kinda validates not stacking them back to back. Did you keep up the copper serum past 6 weeks or call it after you couldn't tell it was doing anything?

Anyone layering GHK-Cu topically with oral BPC-157 for a stubborn Achilles insertion?

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