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BPC-157 + TB-500 split schedule for a cranky Achilles, what timing are you running?

Posted by grinder265 in Protocols & Stacks - 3 points, 4 comments.

Posting this in protocols since im trying to dial in timing, not just pick compounds. Achilles has been a slow heal for me, been on and off BPC for months and its helping but not finishing the job.

Right now im doing BPC-157 at 500mcg split AM/PM subq near the tendon, and adding TB-500 at 2.5mg twice a week. Been running it about 3 weeks, the first week i did TB-500 Mon/Thu, second week i tried Tue/Fri to see if injection site soreness lined up any different with my long run days. Honestly felt about the same, maybe slightly less achy on the long run day when i moved it to Friday morning vs Thursday night.

For those of you running both, are you doing BPC daily and TB-500 2x a week, or pulling BPC back to 5 days on 2 off once you load TB? Also curious if anyone local to the tendon for BPC vs systemic subq actually matters for tendon specifically or if im overthinking that part. Ngl the KLOW framing on the profiles has me thinking about adding GHK-Cu and KPV next, but i wanna get the base stack locked first.

What timing has actually worked for you guys on a stubborn tendon?

Comments

  • fasted_scientist: On the local vs systemic subq thing for BPC, ngl I reckon you're overthinking it a bit. The whole "inject as close to the injury as possible" thing comes from early animal work where they could show concentrated effects at the site, but in humans with subq absorption into systemic circulation it's not really clear that pinning it next to the tendon gets you meaningfully more to the actual tissue. If anything the systemic route probably matters because tendons are poorly vascularised to begin wi
  • grinder265: Appreciate you breaking that down, the poorly vascularised angle actually makes a lot of sense now that you say it. I was kinda stuck on the local injection idea bc every thread online swears by it but never with any real reasoning behind it. Might just stick with subq in the belly and stop pinning next to the tendon, the site soreness alone was annoying So on the timing side what were you gonna say, keep BPC daily through the whole TB load or taper?
  • greg208: That actually makes sense, cheers for breaking it down. Tendons being poorly vascularised is a, I hadnt really thought about it that way. If its getting there through blood anyway then site doesnt matter as much as I thought. I might just stick to belly subq and stop faffing about with placement near the tendon. For timing ive been keeping it simple, AM and PM every day, and not gonna lie the morning dose seems to help more with stiffness through the day.
  • grinder265: Yeah ngl i think youre right that im overthinking placement, the bloodflow argument kinda kills it for me too. Going to move BPC to belly subq and stop pinning near the tendon every time. AM dose helping more with stiffness lines up with what i notice, mornings are noticeably better when i actually get it in before coffee vs skipping til 1030. How long have you been on it daily, and did the AM benefit show up right away or creep in over a couple weeks?

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