NMN vs NR for someone in their 40s, whats actually worth the spend?

Posted by greg208 in Longevity & Anti-Aging - 1 points, 4 comments.

Right so ive been going back and forth on this for weeks and i could do with some real world input. Im early 40s, generally healthy, and the main thing im chasing is keeping my NAD+ levels from doing that midlife nosedive everyone talks about. From what I understand both NMN and NR are supposed to feed into the same pathway but they seem to get marketed very differently.

My main question is what people actually notice day to day. Does one feel more "energising" than the other, or is it the kind of thing where you only see it in bloodwork? Ive also seen people mention timing it with a fast, and im not sure if thats just bro science or if theres a proper reason for it.

Im not against the idea of subq NMN either since ive seen that mentioned a few times in threads here, just want to know if its overkill at my age. Dose wise what are people actually running, and has anyone done baseline bloods before and after to see if theres a real shift?

Also keen to hear from anyone who tried NR first and then switched, or vice versa. Curious if theres a clear winner or if its just personal response. Cheers in advance, this boards been brilliant for cutting through the noise.

Comments

• weekendnate: Honest take from someone in my 30s who tried both, it was a coin flip on how I felt day to day. NMN at 500mg in the morning felt slightly cleaner than NR at 300mg, but the difference was small enough I could chalk it up to a good week of sleep. I never ran bloods for NAD+ specifically because the assays are pricey and kind of a moving target, though I did see my fasting insulin tick down a bit on NMN which could just be noise. Subq NMN is overkill at our age imo, oral gets you most of the way t
• greg208: Yeah the 500mg NMN morning dose is roughly where i was landing too after reading around, so good to hear it from someone actually running it. The fasting insulin drop is interesting, i havent pulled mine in a while so i might get a baseline before i start and then check again in a couple months just to see if anything moves. Subq does sound like overkill, youre probably right, ill stick with oral and save the faff. Cheers for the honest take mate, really useful.
• swims_runner: Yeah i kinda landed in the same place honestly. Tried NMN for like 8 weeks then switched to NR for another 8, nothing dramatic either way. Might have slept a little better on NMN but who knows. Subq seems wild to me for general longevity stuff, id want a real reason before going that route. Oral feels like the obvious starting point 🧠
• greg208: Cheers for that, good to hear im not the only one who didnt get fireworks from either. The subq thing is more of a passing thought than a plan tbh, just kept seeing it mentioned so figured id ask. If you didnt notice much either way did you bother doing any bloodwork or just call it a wash?

Community discussion - research and educational context only. Not medical advice.