Retatrutide TRIUMPH-4 hits 28.7% weight loss, the titration schedule matters here
Posted by weekendnate in Weight Loss & Metabolic - 2 points, 4 comments.
Lilly's Phase III retatrutide data is out and the headline number is 28.7% average weight loss at the higher doses, which is genuinely wild on paper. The part that caught my eye isn't the weight loss though, it's the titration note from the Yahoo piece saying they got within 4% of tirzepatide 15mg results but with fewer titration steps. That tracks with how much of a pain the standard tirz schedule is in practice, and a smoother ramp could mean fewer people bouncing off due to side effects during the early weeks.
My concern is always what happens after the trial ends. People in these studies get dietitians, check-ins, and accountability. Real world results almost always land softer than the trial number, so I'd guess we see more like 20 to 22% in a typical user twelve months out. Still, if the GI side effects stay manageable at the lower titration, this could be a real step up.
Anyone here been tracking their own numbers on retatrutide yet, and how does the appetite suppression feel compared to tirz alone?
Comments
- curious_tracker: Yeah the trial number is eye catching but I keep coming back to what you said about real world vs trial... Most people don't have a dietitian texting them every week. My guess is the average user lands closer to 15 to 18% if they're honest about tracking at the one year mark, the trial setup just sets people up to do better than they would alone. On the titration point though, that part does interest me more than the headline. With tirz the first 4 to 8 weeks were rough for a lot of people I kn
- recovery_optimizer: Yeah, that gentler ramp point is really the story for me too. Less time feeling wrecked in the early weeks means more people actually stick with it long enough to see the real benefit. Hoping the full label reflects what the trial showed there. 🔬
- weekendnate: Yeah, hoping the same. The full label matters more than the press release for once. If Lilly actually keeps the lower titration as the recommended start instead of something aggressive to chase faster numbers, that would tell me they're serious about retention, not just headline weight loss.
- weekendnate: Yeah the 15-18 range sounds more realistic to me too, and honestly anyone self-tracking at twelve months is already in a better subset than the average person who just renews the script and hopes. The dietitian thing is huge, structure does half the work. On the titration, glad you brought up the early weeks nausea because that's where most people I know quit. Are you talking about people on the standard 2.5 to 5mg jump, or the ones who tried splitting doses?
Community discussion - research and educational context only. Not medical advice.