ResearchSafe

TUDCA + oral compounds, did anyone else see liver enzymes actually move?

Posted by vik595 in Safety & Side Effects - 2 points, 2 comments.

Ran a panel before adding TUDCA to my stack a couple months back, mostly because I was running a few oral things at once and wanted a baseline. ALT and AST were both in the high-normal range, GGT slightly above range. Not scary numbers, just a nudge.

Started at 250 mg per day, taken with breakfast. Six weeks in, repeated bloodwork. ALT dropped about 15 percent, AST dropped a similar amount, GGT came back into range. Felt nothing dramatic day to day, maybe slightly less heavy after meals, but that could be placebo honestly. The numbers were the part that surprised me.

Curious if anyone else has tracked this with actual labs and what dosing seemed to do the work. I see the 250 to 500 mg range thrown around a lot. Worth pushing higher if enzymes are stubborn, or does it plateau. And has anyone noticed it interfering with anything, since it changes bile flow.

Also for anyone reading, do not skip baseline labs on this stuff. The whole reason I noticed anything was because I had numbers to compare against.

Comments

  • elle_z: Yeah the labs are really the only reason I trust my own experience here lol. I ran a similar panel around month 2 on TUDCA, maybe 300mg, and my ALT also nudged down, GGT came in too. Felt basically nothing which is what made me doubt it until the numbers showed something 😅 Curious what you were taking alongside, I wonder if the effect looks bigger when there's actual hepatic stress vs baseline liver that was already decent. Mine wasn't in the high-normal range to start so the room to move was
  • vik595: Yeah that tracks, the felt-nothing-but-numbers-moved thing is what made me a believer too. I was running oral BPC and some metformin alongside, so probably some real hepatic load from the metformin at least. Your point about room to move is interesting though, mine were already at the top of range so the drop felt more dramatic on paper than it probably was. If I had clean baseline numbers I bet the signal would be way smaller. I think that's why some people swear by it and others see nothing.

Community discussion - research and educational context only. Not medical advice.