Clomiphene vs Enclomiphene for a subq daily protocol, what is everyone actually running?

Posted by busyliam in Protocols & Stacks - 1 points, 0 comments.

I am looking at putting together a fertility-friendly testosterone support protocol and want to stick with a SERM instead of going on actual TRT, since I still want to keep my own pipeline working, no? I keep going back and forth between clomiphene and enclomiphene and the half-life difference is what is throwing me off the most. Clomiphene has that long 5 to 7 day half-life which sounds like it would give more stable serum readings on paper, but I am reading that the zuclomiphene isomer drags up estradiol in some guys, which is the part I am not wanting to deal with, na?

Enclomiphene seems cleaner to me since it is just the trans-isomer, shorter half-life around 10 to 14 hours, and the research keeps pointing to less estradiol creep. But dosing it daily feels like I am pinning more often than I would like, and I am not fully sure how the pulsatile LH release actually behaves when you clear the drug that quickly versus something that hangs around for a week, you get what I am saying?

For those of you who have actually run one or the other, how did it go in real life? What dose and schedule worked for you, and did you notice anything weird with mood, libido, or water retention? Also did anyone try cycling off after a few months to see if endogenous production held, or is this the kind of thing you end up staying on indefinitely?

Community discussion - research and educational context only. Not medical advice.