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Rhosin reverses blood stem cell ageing in mice, humans still years away

Posted by grinder_derek in Research & News - 1 points, 3 comments.

https://www.drugtargetreview.com/rhosin-shown-to-reverse-blood-stem-cell-ageing/680920.article

Researchers out of Barcelona just showed that Rhosin, a small molecule, can actually reverse ageing in blood stem cells in animal models. The idea is that older stem cells lose their ability to produce healthy blood and immune cells, and rhosin seems to flip that switch back on. It is early, mice level stuff, but the framing around "rejuvenation" rather than just "slowing decline" is what caught my eye.

Honestly this is the kind of paper I want to read twice before I get excited, since "reverses ageing" headlines tend to age poorly once you dig into the methods. I am curious how the effect holds up in human cells, because mouse blood stem cells and ours are not exactly the same shop. Also wondering if anyone here is following the broader rhosin literature, or if this is the first most of you are hearing about it.

For those of us tinkering with longevity stuff, would you actually want a therapy that revives old stem cells, or does that sound like the kind of thing that comes with a nasty tradeoff ten years down the line?

Comments

  • grant_climbs: First time I am hearing about rhosin, so thanks for putting this on my radar. The rejuvenation framing makes me a bit nervous honestly, because when old cells start dividing again you have to ask about mutation load and clonal haematopoiesis, that is the tradeoff that worries me most. I would want to see human cell data before getting excited, and even then I would want long term follow up. Reviving stem cells sounds great on paper until you remember every other time we have pushed proliferatio
  • grinder_derek: Grant raises the exact point I was circling around, that clonal haematopoiesis worry is the one that keeps me up at night with this kind of stuff. Reviving proliferation without tracking mutation burden over time feels like skipping straight to the press conference. I will dig into whether the Barcelona group actually sequenced the rejuvenated cells or just measured functional output, because that would tell me a lot about how seriously to take the framing. For now it is a bookmark, not a plan.
  • grinder_derek: Yeah you nailed the part that made me pause too, the clonal haematopoiesis angle is exactly why I held back from full hype mode. Forcing old haematopoietic stem cells back into cycle without knowing the mutation landscape feels like poking a bear, and we have enough decade-later surprises in oncology literature already. The "rejuvenation" word does a lot of heavy lifting in the abstract that the methods probably do not fully support. I will dig into the Barcelona group's earlier rhosin work and

Community discussion - research and educational context only. Not medical advice.