ResearchSafe

Numbness and tingling in hands, anyone else on MK-677?

Posted by mike65 in Safety & Side Effects - 1 points, 2 comments.

Hey everyone, new here. I have been on MK-677 for about five weeks now, taking it nightly as suggested on the profile page here. Sleep has honestly been great, deeper than it has been in years, and my recovery in the gym seems better too, though that could just be placebo, who knows 🧬

But the thing that is bugging me is this tingling and numbness I keep getting in my hands and fingers. Mostly at night and in the morning when I first wake up. It is not constant, but it shows up pretty often. I read that numbness and tingling is listed as a possible side effect, which is reassuring I guess, but I wanted to ask if anyone here has dealt with it and if it went away over time.

Also kinda worried about the elevated blood sugar part since that runs in my family. I am planning to get bloodwork done soon to check fasting glucose and IGF-1 levels. For those who have been on it longer term, did your numbers move much? Trying to stay ahead of stuff before it becomes a real problem. Thanks for any input, this forum seems like a good place to actually learn the right way.

Comments

  • paige_sauna: Interesting, I have read that the tingling thing is from MK-677 messing with insulin and glucose, which can throw off nerve signalling, especially overnight. Anecdotally a few people I have seen say it fades after a few weeks as the body adjusts, but I would not bank on that. With your family history of blood sugar stuff I would push that bloodwork up sooner rather than later, fasting glucose, fasting insulin, and HbA1c would give you a way better picture than glucose alone since insulin can be
  • mike65: Thanks for breaking that down. I did not think about fasting insulin and HbA1c, just glucose. I will ask my doc to add those when I go in. The neck thing is a good call too, I sit at a desk all day so that is probably not helping anything. Anecdotally the tingling does seem a bit better this week but I am not sure if that is real or I am just getting used to it. How long did it take for you to settle in on it, or did it never fully go away?

Community discussion - research and educational context only. Not medical advice.