MK-677 at night vs morning, does timing actually matter for sleep?

Posted by fasted_scientist in GH & Growth Peptides - 2 points, 0 comments.

Right so I've been going back and forth on this and ngl I keep flip flopping. Most stuff I've seen says MK-677 in the evening because the sleep deepening effect is kind of the whole selling point, and you stack it with the natural night time GH pulse.

But then I think about the 24 hour half life and wonder if it actually makes any meaningful difference. Like if you're taking it in the morning, by bedtime you've still got decent levels on board right? I've seen people claim morning dosing kills their productivity because of the lethargy, which I get, but I've also seen people say evening dosing makes them groggy the next day.

For me personally (and this could just be placebo, who knows) evening felt better for sleep quality but I woke up feeling a bit sluggish. Switched to right before bed and the grogginess seemed worse actually.

Curious what others reckon. Is there any actual data on timing or is this all just bro science at this point? And does anyone pair it with ipa at night or is that overkill?

Community discussion - research and educational context only. Not medical advice.