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CagriSema first 6 weeks, my numbers vs how I actually felt

Posted by tiredmira in Weight Loss & Metabolic - 1 points, 2 comments.

Finally pulled the trigger and started cagrilintide + semaglutide about 6 weeks ago after stalling out on tirz for a couple months. I have a whole spreadsheet because i am who i am, so here is the boring stuff first.

Weight dropped from 184 to 172, so basically 12 lbs in 6 weeks. Waist down about 1.5 inches. Food noise is way quieter than on tirz alone, like a different category, which surprised me because i did not expect cagrilintide to feel that different. Morning fasting glucose averaged 92 over the last 3 weeks vs 99 the 3 weeks before starting.

Side effects were rougher than i expected. Nausea days 2-4 after each dose bump, and the constipation on cagrilintide is no joke, i had to actually add magnesium citrate daily. Sleep HRV dipped the first 2 weeks then came back to baseline.

I titrated slower than the trial schedule because the side effects were real. Still at half the target dose right now and already losing. Curious if anyone else titrated slow on purpose and what your pace looked like. And for those who hit the full 2.4/2.4, when did the appetite suppression actually peak for you? 🥗

Comments

  • runner_aaron: Howzit. Congrats on the progress man, that spreadsheet dedication is something I respect tbh. The slow titration thing makes sense. I haven't run cagrisema myself but on tirz the difference between jumping the standard schedule and going slower was night and day for the nausea. I ended up staying on a dose for an extra week each step and the side effects basically disappeared after week 3. Quick question though, did the HRV dip bother you subjectively or was it just the numbers looking rough?
  • tiredmira: The HRV dip was numbers only, I actually slept fine and training felt normal those first two weeks. That's why I waited it out instead of panicking. Anxious is real though, I get why you would flag it.

Community discussion - research and educational context only. Not medical advice.