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Tirzepatide stalled at week 10, curious about layering in amlexanox

Posted by weekendnate in Weight Loss & Metabolic - 1 points, 2 comments.

Been on tirzepatide since late summer, titrated up slow and steady, and the first eight weeks moved the needle like I expected. Then around week 10 things just... Flattened. Still suppressing appetite fine, training volume is the same, sleep is steady, but the scale barely budged for two and a half weeks and my weekly average on weight is sitting right where it stalled.

Bloodwork from last month looked clean, fasting insulin dropped from 9.2 to 5.8, hsCRP is down, lipids actually got better not worse. So nothing obvious is broken. Could just be a normal adaptation pause that breaks on its own.

I've been reading about amlexanox and the IKKε and TBK1 angle is interesting since the proposed mechanism is restoring thermogenesis rather than just killing appetite. Has anyone actually tried adding it during a GLP-1 plateau? Wondering if the energy expenditure side does something the GLP-1s don't, or if it's mostly redundant once you're already eating at a deficit.

Comments

  • tiredmira: Genuinely curious about this one too. I know some folks who stack retatrutide when a GLP-1 stalls and that seems to work, but adding a totally different mechanism like amlexanox is a different bet. The thermogenesis angle is what caught my eye too. Appetite suppression only solves half the problem, and if you've been in a deficit for months your body has probably downregulated energy output pretty hard. Could just be that, honestly. I'd want to see your NEAT trends before adding anything thoug
  • weekendnate: Yeah steps are still there, I've been averaging around 9-10k daily and my standing desk time hasn't changed. NEAT looks fine on paper. The retatrutide route is interesting but I want to stay on tirz for now since the appetite control is still working great. The whole reason I'm looking at amlexanox is exactly what you said, the energy expenditure side, because killing more appetite doesn't fix a body that's decided to burn less. Did you see anything on the dosing in the human studies? The 200m

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