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CGM data on tirz vs a week I added amlexanox, sharing the screenshot breakdown

Posted by tiredmira in Weight Loss & Metabolic - 1 points, 2 comments.

So I've been on tirz for about 8 months now and stalled in a weird place. Like the scale moves a pound either direction but my CGM tells a different story some weeks. Mostly glucose is fine but my fasting insulin trend on bloodwork was creeping up and I was annoyed by it.

Decided to run a 3 week test with amlexanox at 50mg three times a day. Wanted to see if anything moved. I logged everything, food was basically identical week to week.

Honestly the CGM was the most interesting part. My average glucose dropped about 6 points. Time in range went up. And weirdly my afternoon energy felt more stable, less of that 3pm dip I usually blame on my toddler 😅

Weight on the scale barely moved. Like half a pound difference, totally within noise. But the metabolic stuff looked different enough that I'm gonna run another 4 weeks and pull bloodwork to actually see if fasting insulin or lipids moved.

Anyone else stack amlexanox with a GLP-1? Curious what numbers you tracked.

Comments

  • grinder265: Interesting ngl, amlexanox is one of those weird ones where the human data is thin but the mechanism story for IKK/NF-kB makes sense on paper. How are you sourcing the 50mg tid dose, that seems high compared to the topical oral ulcer studies i've seen. Also did you notice any GI stuff stacking it on tirz or was it clean? My main concern would be liver enzymes over a 3-4 week run, did you baseline ALT/AST before starting or are you waiting for the longer block to pull those?
  • tiredmira: Yeah the dose is the part I waffled on the longest. I went with 50mg tid because the human data on metabolic stuff is basically just that one small tudca-style trial and the math felt off below it. GI was honestly clean, no nausea on top of tirz which surprised me. No baseline liver enzymes yet, waiting for the 4 week pull so I have something to compare to 😅

Community discussion - research and educational context only. Not medical advice.