Spermidine log week 3, plus a question about stacking with rapamycin later

Posted by sanjay_j602 in Longevity & Anti-Aging - 1 points, 2 comments.

Okay so I started spermidine about three weeks back, the polyamine kind, and I genuinely did not expect to feel anything but my face looks less puffy in the mornings and my skin just looks a bit more even, could absolutely be placebo or could be the autophagy thing finally kicking in, I am not going to pretend I can tell. I am taking it once a day in the morning on an empty stomach and that seems to work fine, no GI stuff for me so far which I know can happen. The thing that got me curious enough to start was reading about it inducing autophagy and basically mimicking caloric restriction without the actual fasting, and at 30-something in Singapore with the kind of sleep and training load I put myself through, anything that helps cellular clean-up sounds worth a shot to me.

Now the question part, has anyone here tried layering spermidine with low dose pulsed rapamycin down the line? I know rapamycin also hits the autophagy pathway through a different mechanism (mTOR inhibition) and I am trying to think through whether stacking makes sense or if that is just asking for too much immunosuppression. Would love to hear what others running a longevity stack have done.

Comments

• sean_h: Honestly the skin thing took me by surprise too, started noticing my under-eyes looked less heavy after maybe 2 weeks in, no idea if it is the autophagy or just better sleep lining up by coincidence, but I will take it. On the rapamycin question, that is a whole different beast mate, you are talking about a prescription immunosuppressant that needs a doc on board and proper bloodwork, not something you just slot in next to your spermidine and hope for the best. I would be chatting to someone who
• sanjay_j602: Yeah the under-eye thing is real for me too, same kind of timeframe, probably a couple weeks in I looked in the mirror one morning and thought okay that's different, whether it is autophagy or just finally sleeping through properly I cannot say but I will take it too haha. And yeah you are right about rapa, I know it is not something you pick up and stack casually, that is literally why I asked, I was curious if anyone had actually run it under a doc and what their bloodwork looked like before g

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