HCG on TRT and noticeable estradiol rise – anyone else see this?

Posted by quinn_swims in Safety & Side Effects - 1 points, 2 comments.

I’ve been running 500 IU HCG twice weekly alongside my TRT for about six weeks. For me it seemed to keep my testicular size stable, which was the main goal. Around week three I started feeling a bit bloated and noticed mild breast tenderness that wasn’t there before. I got bloodwork done and my estradiol had jumped from roughly 20 pg/mL to about 45 pg/mL, while my total testosterone stayed in the target range.

Comments

• elle_z: Yeah this happened to me too, took me by surprise actually 😅 i was on 250iu twice a week (so half your dose) and still saw e2 creep up after about a month, the nipple thing was the first clue lol. For me cutting the dose down and being more consistent with the timing helped a lot, like i was sloppy with days before. Anastrozole is the usual answer people reach for but i tried to avoid it, my sleep already suffers if my e2 drops too low. What does your trough bloodwork look like, are you testin
• quinn_swims: Mine was drawn about 72 hours after my last pin, so close to trough I think. Your point about consistency is fair, I was doing monday/thursday but some weeks shifted by a day or two. Cutting dose to match yours is interesting since you still saw the rise on 250iu. At what number did your e2 actually settle after you lowered it?

Community discussion - research and educational context only. Not medical advice.