Rapamycin + spermidine together, anyone stacking these?

Posted by rachel61 in Longevity & Anti-Aging - 1 points, 2 comments.

Ok so I have been on low dose rapa once a week for a few months now for what it is worth, started mostly for the immune rejuv angle since I am getting older and tired of getting every cold that goes around. Going ok so far, mouth sores were rough the first couple weeks but they chill out if I stay hydrated and skip acidic stuff that day.

Reading more about spermidine lately and it sounds like it does something similar, autophagy but thru a different path. The profile says it mimics caloric restriction signaling too. So I am wondering if stacking them is redundant or actually smart, like hitting the same end result from two angles.

Is anyone here actually running both? Curious how you timing it relative to the rapa dose day, and whether you noticed anything extra or if it just felt like noise. Also did you notice any GI stuff from the spermidine, I am a little sensitive there.

Not looking for a protocol, just real experiences from people who have tried it.

Comments

• tiredmira: I have run rapa weekly for about 6 months myself, also went down the spermidine rabbit hole for the same reasons you are describing. What I read suggests they hit overlapping but not identical autophagy pathways, so in theory the combo is not redundant but also not something with strong human data behind it. For me personally I tried spermidine daily on non-rapa days for about 5 weeks, nothing dramatic to report, no GI issues, sleep scores basically flat, HRV basically flat. The interesting pa
• rachel61: Hey thanks for the actual breakdown, that helps a lot. The day before angle is interesting, I had not thought about timing it that way. Do you recall roughly how big the recovery bump was, like noticeable on the watch or more of a subjective thing, and did you keep that schedule or go back to daily?

Community discussion - research and educational context only. Not medical advice.