ResearchSafe

Scalp irritation after switching to 75 mg/mL RU‑58841 – what’s normal?

Posted by amber464 in Safety & Side Effects - 1 points, 2 comments.

I’ve been using a 75 mg/mL RU‑58841 solution for about three weeks now. I started with 0.5 mL daily on the crown and gradually moved to 1 mL total split between front and crown. The first 4‑5 days I noticed a mild tingling that went away, but by day 8 a dry, flaky patch appeared behind my left ear. It’s not painful, just itchy and a bit scaly. I rinsed with a gentle sulfate‑free shampoo and applied a light moisturizer, which seems to calm it down a bit, but the area still looks slightly red compared to the rest of my scalp.

My HRV and sleep haven’t changed, and I haven’t added anything else to the stack. I’m wondering if this is a typical early‑stage irritation that will subside, or if I’m reacting to the vehicle. Has anyone else seen similar timing or severity? Any tips on soothing the skin without compromising the anti‑androgen effect? I’m planning to keep the dose the same for now, but open to adjusting if needed.

Comments

  • val109: I had a similar thing when I first tried a 75 mg/mL batch a few months ago. The first week I felt a faint tingling that went away, then around day 7‑9 a small dry spot showed up near the hairline. For me it was just a bit itchy and flaky, not painful. I found that keeping the scalp clean with a very mild, sulfate‑free shampoo and applying a thin layer of a non‑comedogenic moisturizer (I used a simple aloe‑gel mix) helped the barrier recover without seeming to dilute the drug. I also cut the dai
  • amber464: Thanks for the details, val109. I actually tried cutting the volume in half for two days after the patch showed up and it did feel less itchy, but the dry spot stayed the same size. I stuck with the aloe‑gel mix you mentioned – it’s helped the flakiness a bit. I’ll keep the full dose for now and monitor, but might do another short cut‑back if it gets worse. Did you notice any change in hair‑shedding when you dropped the volume?

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