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BPC-157 in rats again, does any of that actually carry over to grumpy tendons

Posted by grinder265 in Healing & Recovery - 1 points, 6 comments.

https://thearmdoc.co.uk/peptides-for-injury-recovery-what-the-evidence-actually-says

Thearmdoc.co.uk piece walks through what BPC-157 and a few other peptides actually have behind them, mostly rat data on tendon, ligament, and bone healing at tiny doses. The author is pretty clear that almost everything compelling is preclinical and that human evidence is thin.

That part actually tracks with how I think about it. The vascular and fibroblast stuff in rodents is interesting, but rats heal tendons differently than we do, and a lot of the loud claims online skip right over that. I have tried BPC around a grumbling supraspinatus and subjectively the area calmed down faster, but that is just my own experience and could easily be timing with physio.

Curious if anyone here has run it both locally and systemically for the same tendon issue, and whether one clearly edged out the other.

Comments

  • fasted_scientist: You're spot on about the rat-to-human jump being the dodgy bit. Ngl, the fibroblast and angiogenesis stuff looks tidy in rodents, but rats heal differently and their tendons aren't loaded the same way ours are. For me, I ran BPC both ways on a niggly Achilles. Local injections around the tendon seemed to do more than subq in the belly, but I'm fully aware that's just my own experience and could easily be placebo plus the time I was resting it properly. Did you stack anything with it, or just BP
  • weekendruby: Just bpc on its own, no stack. The local thing is interesting though, basically if i'd had access to inject near the tendon i probably would have tried that too. How long did you run it before you noticed anything different?
  • grinder265: Ngl it was about 10 days before the supraspinatus stopped flaring up on overhead movements, but I was also doing rotator cuff work the whole time so hard to say what did the heavy lifting. You ran yours oral or subq? Curious because if you went subq systemic and still felt something that kinda supports the idea that local delivery isnt the only path.
  • tiredmira: I just used BPC on its own that round, wanted to keep it simple and see if I could actually tell anything 😅 Local definitely made more sense to me too though, subq felt like throwing darts blind.
  • grinder265: Yeah the darts blind analogy is pretty accurate honestly. Subq just felt diffuse in a way that made it hard to attribute anything. What local route did you go with for yours, IM into the site or actual peritendon injection because I have seen both thrown around and the logistics of doing it yourself get weird fast.
  • grinder265: Local vs subq is exactly what I was curious about, good to hear your Achilles responded more to local. I ran it solo both ways, no stack, just BPC on its own around the supraspinatus and then later subq. Ngl the local felt marginally more targeted but the difference was small enough I cant really call it. How long did you run the local protocol before deciding it was doing more?

Community discussion - research and educational context only. Not medical advice.