New fisetin senolytic trial out, intermittent dosing still looks smarter than daily

Posted by weekendnate in Research & News - 1 points, 0 comments.

Saw a fresh paper land this week building on the Mayo fisetin work, this time looking at intermittent "hit" dosing versus daily in older adults. The hit-and-run group kept the senolytic signal and had fewer GI complaints, which honestly matches how I have been timing mine around heavy training blocks for a while now. Daily just feels like you are asking for tolerance and gut issues for no extra benefit.

The interesting part is they are finally tracking actual functional outcomes, not just biomarker stuff. Walking speed, grip strength, that kind of thing. Still small numbers and short follow up, but it is a step in the right direction.

What I keep wondering is whether the absorption problem is the real ceiling here. Most fisetin studies use formulations that boost bioavailability, and I do not see anyone talking about that gap in the popular write ups.

Anyone here pair it with a fat source or a liposomal version and notice a difference on how you feel the next day? Curious if that is placebo or actually doing something.

Community discussion - research and educational context only. Not medical advice.