ResearchSafe

Sermorelin + high-dose NR, flushing turned into a nightly thing for me

Posted by weekendnate in Safety & Side Effects - 1 points, 2 comments.

I started sermorelin about 6 weeks ago, 250 mcg before bed, subq. Sleep got noticeably better within the first week, deeper and I wake up less, which was the main reason I tried it. Around week 3 I also bumped NR up to 600 mg daily for an NAD push.

That's when the flushing started. Mostly face and chest, sometimes ears, usually 20 to 40 minutes after the sermorelin shot. I thought it was the NR at first because niacin-related flushing is a known thing even with non-flush forms. Took it on separate nights to test. Flushing happened on sermorelin-only nights too, just milder. On nights I did both it was louder and stuck around longer, an hour plus some nights.

HRV has been flat through all of this, resting heart rate unchanged, bloodwork last week showed nothing weird. So nothing alarming, just annoying and a little uncomfortable. I have read that flushing is on the side effect list for sermorelin but I had not seen anyone describe it stacking with NR.

Anyone else running both notice this, or am I just sensitive to one of them? Going to drop the NR back to 300 mg and see if it calms down before I touch the sermorelin dose.

Comments

  • patient_codes: Interesting, I haven't stacked the two so I can't speak to that combo directly, but I've had sermorelin flushing show up on its own a few times too, mostly when I dosed right after a hot shower or a warm meal. The vasodilation thing seems pretty dose and context dependent from what I've read, and adding something like NR on top might just be amplifying an existing response rather than causing it 🧠 The plan to drop NR to 300 first sounds reasonable to me, easier to isolate which one is doing it
  • weekendnate: Yeah, hot showers definitely make mine worse too, good call. I'll try dosing on a cooler night and see. Bloodwork was just a standard panel, nothing fancy like CRP or anything inflammatory. I can ask for that next round, makes sense to actually check instead of guessing. Cutting NR to 300 starting tonight, then maybe skip it entirely on shot nights for a week to compare. I'll report back with what the data looks like.

Community discussion - research and educational context only. Not medical advice.