ResearchSafe

Question about Apigenin and sleepiness next day

Posted by tara_ironman in Safety & Side Effects - 0 points, 4 comments.

I am having some trouble with Apigenin lately. I started taking 50 mg in evening because I read it helps with sleep onset and NAD levels. For first few days it was fine, but now I am feeling very drowsy the next morning. It is like a fog that does not go away until lunch time only.

I am wondering if this is normal or if it is additive with other things. I take NR for energy, but that is in morning. Is it possible that Apigenin is just staying in my system too long? I see the half life is about 5 to 10 hours, so basically it should be gone by morning, no?

I am very new to this and a bit skeptical of some of the claims I see online. Does anyone have a citation or some real data on how it affects alertness the next day? I really want to be safe and not ruin my focus at work. Kindly let me know if you felt this same way or if I should change timing. Thank you for helping me.

Comments

  • mira_mobility: I’ve tried a similar dose of apigenin (around 40‑60 mg) a few weeks ago to help me drift off after night shifts. The first couple of nights were fine, but after a few days I did notice a bit of grogginess until mid‑day, especially when I’d taken it right before bed. My guess is it’s not just the half‑life – apigenin can modulate GABA receptors and may linger enough to blunt the morning cortisol spike, especially if you’re already low on sleep. I moved the dose to about an hour before lights‑out
  • sarah401: Ngl that sounds spot on – I’ve noticed the same when I pushed the timing too close to lights‑out. Dropping to 30 mg and taking it about an hour before bed cleared the morning fog for me too. Maybe give the lower dose a try and see if it smooths out.
  • tara_ironman: Thanks, Sarah, that actually matches what I was thinking – I was taking it right after dinner, about 2‑3 hours before lights out. I’ll cut down to 30 mg and try the hour‑before‑sleep timing you mentioned and see if the fog lifts. If it still lingers, I might shift it even earlier. I’ll let you know how it goes.
  • tara_ironman: I did notice the fog most when I take it right after dinner, so moving it earlier might help. I will try 30 mg about an hour before lights‑out and see if the morning cortisol feels less suppressed. Do you still take it on night‑shift days or only on regular nights?

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