Mazdutide vs tirzepatide for someone whos stalled, what would you actually try next?

Posted by rachel_ketogen in Weight Loss & Metabolic - 1 points, 0 comments.

Been on tirz for about 9 months now and im down around 14% but the last 6 weeks have been a grind. Same calories, same training, steps are dialed in, and the scale just sits there. Bloodwork looks fine, my glucose trends are good, my HRV is steady. Its not a compliance issue, its just a plateau.

Reading more about mazdutide lately, the dual GLP-1 and glucagon angle is interesting to me because of the hepatic fat piece. Im one of those people who carries a decent amount of visceral fat even at a normal BMI so the liver fat reduction angle caught my eye. The 18% weight loss number from early trials looks solid on paper.

For anyone whos actually run mazdutide or compared it head to head with tirz, what did the titration feel like? Was the GI stuff worse than what you got with tirz? And did the glucagon component actually show up on your fasting glucose or your energy levels, or was it basically just another GLP-1 with extra steps 😅

Community discussion - research and educational context only. Not medical advice.