Trying low-dose rapamycin once a week – what I noticed after two months

Posted by patient_codes in Longevity & Anti-Aging - 2 points, 2 comments.

I’ve been curious about rapamycin for a while so I decided to try a low dose of 4 mg once a week for eight weeks, just to see how it felt. I’m a CrossFit coach so I pay close attention to recovery, energy and how my skin looks after tough workouts. The first couple weeks I didn’t notice much, just a tiny bit of dry mouth here and there which I managed with extra water.

By week three I felt like my muscles were bouncing back a bit faster after heavy squat sessions, less that deep soreness that usually lingers into the next day. My sleep seemed a touch deeper too, I woke up feeling less groggy even on early morning class days. Around week five I started getting occasional mild mouth sores, nothing painful but annoying enough that I started rinsing with salt water after meals.

I also noticed my skin looked a bit more even, less redness after a hard metcon, though I can’t say if that’s the rapamycin or just the extra hydration I’ve been doing. I’m planning to take a break for a month and then maybe try a slightly lower dose to see if the sores go away while keeping the recovery benefits. Would love to hear if anyone else has tried a similar pulse and what they noticed.

Comments

• retired_coldplunge: The mouth sores showing up around week five is a pretty common pattern from what I've seen people report, even on lower doses. Sounds like your body's starting to flag something, and the month off is a smart call before you try adjusting down. A few things I'd wonder about, fwiw: did you get any baseline bloodwork done before starting? Lipids, glucose, those kinds of markers? The recovery benefits you're describing are interesting but it's one of those areas where it's really hard to separate w
• elle_z: Yeah baseline bloods is the thing i keep coming back to with rapamycin, you really need a before pic for glucose and lipids because that's where the sneaky changes hide. And honestly even the recovery stuff could just be a good block of training, hard to tell 😅

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