Dihexa oral at 10mg, am I supposed to feel it the same day or is this a slow build

Posted by retired_coldplunge in Cognitive & Nootropic - 1 points, 2 comments.

Started Dihexa oral about two weeks ago at 10mg daily, fwiw. I had this expectation (probably from reading too many hyped-up threads) that I'd notice something dramatic pretty quick, like the way Semax hits you within minutes.

For me it's been way more subtle. The first few days I actually felt kind of flat and had a dull headache by late afternoon. Not terrible, just enough to notice. I stuck with it because I'd read that the adjustment period can be rough.

Around day 9 or 10 I started feeling like my recall was a bit sharper, especially with names and the stuff I always lose at the tip of my tongue. Could just be placebo though, honestly. I haven't had any of the insomnia that some people mention but I'm also pretty careful about taking it before noon.

I guess my real question is, for those of you who've run Dihexa for longer, when did it actually click for you? I keep seeing people talk about synaptogenesis like it's something you'd feel, but I suspect this is more of a cumulative thing that shows up over weeks or months rather than days.

Also curious if anyone has gone from 10mg to 20mg and whether that made a noticeable difference or just cranked up the headaches. I'd rather not push it if the lower dose is doing its job quietly. 😎

Comments

• student_rational: Yeah its def a slow build for most people, didnt hit me till around week 3 and even then it wasnt a light switch, more like i stopped losing words mid sentence and just felt a little more "on" when reading dense stuff. The flat headache thing in week 1 is super common, id give it another week or two before judging it. On the dose bump, i went from 10 to 20 and honestly the headaches got worse without a clear upside, so i went back down. Some folks swear by 20 but i think 10 is a better starting
• elle_z: Yeah same here actually, i was on 10 for almost a month before i even noticed anything worth mentioning, just felt a bit sharper at my own notes and easier to stay locked in when reading, nothing dramatic. I never went above 10 though cos the headache thing already put me off lol. Gonna ride it out at this dose and see where i land ⚡
• elle_z: Yeah that tracks with what I've heard, the "stopped losing words" thing is a really good way to put it lol. And yeah staying at 10 sounds smart, I'll give it the full month before I even think about touching the dose. Appreciate the input 🙏

Community discussion - research and educational context only. Not medical advice.