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Running KLOW and adding Pentosan oral, overkill or actually sensible for an old knee?

Posted by runner_aaron in Protocols & Stacks - 1 points, 4 comments.

Hey everyone. I've been on a KLOW run for about six weeks now, standard setup, BPC and KPV daily, TB-500 and GHK-Cu two times a week. The whole reason I started was a grumbling right knee, the kind that nags on stairs and after long runs.

I've been reading up on Pentosan polysulfate, the oral route specifically, because jabbing the knee isn't really an option I want to keep doing long term. My plan would be to layer it in alongside KLOW, not replace anything, just add it in weeks 7 to 12 and see if the knee settles.

For those of you who've stacked Pentosan oral with a KLOW type protocol, how did you actually time it? Morning, split dose, with food? And did you keep the BPC and KPV going daily or taper them off so you're not doubling up on the inflammation coverage? Genuinely curious if anyone found the combo too much, or if it actually moved the needle on a stubborn joint. Bloodwork before and after is a given, but I'd rather hear what timing people landed on before I start.

Comments

  • grinder265: Ngl i havent run oral pentosan alongside a full KLOW so take this with a grain of salt, but for my grumpy knees i ran PPS oral solo for about 8 weeks after tapering BPC down, not stacking everything at once. Felt cleaner than trying to figure out which thing was doing what. The standard dosing math i looked at was something like 3 to 6 mg/kg per week split into 2 doses, with food, mornings and evenings. Seemed to take a few weeks before i noticed anything and bloods were fine. If youre gonna la
  • runner_aaron: Appreciate that, the solo approach actually makes sense for pinning down what is doing what. How long did you taper BPC down for before starting PPS, and did you keep KPV in or drop that too? I'm weighing whether to just run PPS alone for a few weeks after finishing my current KLOW cycle rather than overlapping everything.
  • former_codes: Yeah, running solo first makes total sense, otherwise you really have no clue what did what. The mg/kg math you mentioned is roughly what I remember from the older papers on PPS too, although for the oral form I think the actual absorption is pretty low so the effective dose hitting the joint is probably less than what you'd get from an injection. I would personally want a decent washout from the BPC before adding PPS just so the picture stays clean, but that is just my preference. Did you notic
  • runner_aaron: Tbh I haven't run solo first, the KLOW has been going about six weeks already and that's the point I'm at now. So a proper washout isn't really on the table unless I stop everything for a bit. Lipids and platelets were fine last check, nothing jumped out, but I was only on KLOW at that point so I can't say what PPS would do on top. That's partly why I'm hesitant, I won't know if a weird reading later is from one thing or the combo. The oral absorption point is fair though, does that mean most

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