Layering serrapeptase into a KLOW run for gnarly post-long-run ankle swelling, smart add or overkill?

Posted by grinder265 in Protocols & Stacks - 1 points, 3 comments.

Been running a KLOW base for about 6 weeks now, mostly for a cranky peroneal that was not cooperating with just BPC and TB solo. Healing is moving, ankle is happier, but I still get this annoying swelling around the lateral malleolus after anything over 20 miles. Like pitting edema that sticks around for 2 days.

So I have been thinking about adding serrapeptase on the back end, specifically on long run days and the day after. Planning to dose it empty stomach, morning of and morning after, well away from the BPC pin and any food. The idea is the fibrinolytic action might help clear whatever fluid and fibrin buildup is hanging around the tendon sheath while KLOW does the actual repair work underneath.

Ngl I am a little nervous about stacking an enzyme that touches fibrin with a stack that already promotes angiogenesis. Am I overthinking this or is the timing separation enough? Anyone actually run KLOW plus serrapeptase and notice the swelling piece shift, or did it not move the needle?

Comments

• leah_vo2max: Interesting question, been curious about this exact combo myself. I have run KLOW solo and got most of the healing benefit but the swelling on long days was always the last thing to budge for me too. To be fair I never added serrapeptase into the mix, so this is more questions than answers, but the fibrin angle makes sense on paper. Timing separation around the BPC pin and food seems reasonable to me, the half life is short so I would not stress too much about overlap. Did you check for actual
• grinder265: Yeah I have been digging into the clot angle too, and ngl that is the part that keeps me up at night a little. No DVT history personally, no varicose issues, bloodwork in October was clean across the board including d-dimer. I do pop ibuprofen maybe once every two weeks after a really bad long run but I would skip it entirely on serrapeptase days, not even worth the risk math. My bigger concern is actually more theoretical, like does a systemic fibrinolytic blunt the angiogenesis signal that BP
• grinder265: Yeah the fibrin angle is what sold me on trying it honestly. And no dvt history on my end, nsaids are minimal maybe once a month for a headache. Ngl tho your point about half life being short is a good one, i was overthinking the spacing from that angle.

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