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KLOW + GH split for a stubborn elbow, does this timing actually make sense

Posted by leah_vo2max in Protocols & Stacks - 1 points, 6 comments.

Been running KLOW for about 6 weeks now for a cranky medial epicondyle that's been nagging me since spring, to be fair it's the first thing in 2 years that's actually moved the needle on it.

My current setup, BPC and KPV daily AM, GHK-Cu and TB-500 2x weekly on training days. I'm also on a low dose GH pulse, 2iu fasted morning 5 days on 2 off, and that's where my question is.

The GH half life is short but the downstream IGF-1 signaling sticks around way longer, and i'm wondering if pinning GHK-Cu on the same morning as my GH shot is actually a waste or if the copper peptide signaling stacks ok with the IGF axis. Same question for TB-500 honestly, those i usually save for leg day though so it's not a daily overlap.

Also does KPV need to be split or is once daily fine if i'm not flaring. Right now it's just one shot AM next to the BPC. Reconstituting KPV separately has been the most annoying part of the whole stack tbh.

Anyone running KLOW alongside GH and figured out the timing that actually feels right?

Comments

  • cycles_dad: Honestly the KPV once daily has been fine for me even when i'm flared up, but i'm not your elbow lol. Splitting it is more of a "if you feel like it" thing imo, not a must. For the GH timing question, that's the part i'd be curious about too. The copper peptide stuff and IGF-1 are doing pretty different jobs in the tissue, so i wouldn't expect them to flat out cancel each other, but whether they actually stack well same morning... I dunno, i've seen people on here do it both ways. I'd probably
  • retired_coldplunge: The "different jobs in the tissue" framing makes sense to me. I've been pinning GHK-Cu on training days same morning as my GH shot for weeks now and honestly can't tell if it's doing more or less than it would split out. Could just be that the elbow is slow to respond either way, eh. Fwiw the one thing I'd watch is whether you're getting enough copper systemically from the GHK to matter at all, or if it's mostly local where you pin it. That might answer the stacking question more than timing do
  • leah_vo2max: The systemic copper thing is a I hadn't really parsed out. To be fair i've been treating GHK more like a localized wound healing signal than anything that moves the needle systemically, but if the doses people run even approach meaningful copper contribution that's a different conversation than just the peptide signaling piece. My elbow is the same deal, stubborn doesn't even cover it, been at this for months.
  • erin_rows: Grand shout cycles_dad, and yeah spot on, the two are doing different jobs so they're probably not cancelling each other out. Tbh i'm leaning towards spacing them anyway, just keeps the variables cleaner when i'm trying to figure out what's actually working on the elbow.
  • leah_vo2max: Yeah that was my gut too, to be fair splitting just feels safer when i'm trying to actually track what's helping vs what's just noise. Gonna move GHK-Cu to evenings and keep TB-500 with leg day like you said, no reason to stack them all on the GH pulse morning.
  • leah_vo2max: Fair point on the KPV, I might just leave it as one shot AM and not overthink it. The GH + GHK-Cu overlap is really what's bugging me tho, like if the IGF-1 cascade is still humming for 12-18 hrs after my shot and I'm pinning copper peptide right into that window, am I getting the full effect of either or both. To be fair I haven't noticed a downside, but I'm 6 weeks in and the elbow is still a project so I'm trying to figure out if moving GHK-Cu to an off day would be worth testing for a few w

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