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BPC‑157 and oral Pentosan for my stubborn rotator cuff tendonitis

Posted by aspiring_codes in Healing & Recovery - 2 points, 2 comments.

Hey all, I finally decided to try a combo after months of nagging rotator cuff pain that just wouldn’t chill out with physio and ibuprofen. I started BPC‑157 sub‑Q at about 250 mcg daily, split into two injections around my shoulder (morning and evening) right after my PT stretches. A few days in I added oral Pentosan Polysulfate – 100 mg three times a day – mostly because I read it can boost cartilage proteoglycans and seemed low risk.

For the first week I felt a slight warm sensation in the joint after the BPC‑157 shots, but my range of motion improved a bit and the ache was less sharp during overhead lifts. By week three the night‑time soreness was almost gone and I could do light dumbbell work without that “creak” I always heard. I did get a mild headache once, probably from the Pentosan, but it cleared up.

Just sharing my timeline – not a recommendation – in case anyone’s tried a similar stack or has thoughts on dosing timing with rehab. 👀

Comments

  • amber464: Hey For me I tried BPC‑157 sub‑Q around 200 mcg daily for a nagging elbow tendonitis last fall and also felt that brief warmth right after the shot, though I didn’t add Pentosan. My pain dropped enough to resume light band work after about two weeks, but I noticed the improvement plateaued once I stopped the daily injections and relied only on PT stretches. I’m curious if you kept the Pentosan going after the soreness faded or tapered it off, and whether you tracked any objective markers like sh
  • aspiring_codes: I kept the Pentosan at 100 mg TID for the full six weeks – never tapered because I didn’t want any dip while the B‑pep was still coming off. After the soreness cleared I stopped the BPC‑157 at week 4 and just kept the oral. I did start logging my external rotation angle with a goniometer (got up to ~70° from ~55° pre‑start) and used the same PT stretch routine each day, so the numbers backed up the “feel” improvements. 👀

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