Survodutide glucagon arm, anyone splitting out the energy expenditure vs pure appetite effects?

Posted by weekendnate in Weight Loss & Metabolic - 1 points, 4 comments.

I've been digging into survodutide and the glucagon piece is what caught my eye. Most GLP-1s I'm tracking on myself move the needle through appetite and that's about it. Adding glucagon receptor activation supposedly pushes energy expenditure too, which is a different lever.

For those of you who have run it, did you actually notice a metabolic bump beyond eating less? I'm thinking resting HR up a touch, slightly warmer sleeping, maybe HRV dipping before weight starts moving. Or was the experience indistinguishable from a strong GLP-1 monotherapy for you personally?

I'm also curious how the titration felt compared to tirz. The 0.6 to 6 mg weekly range looks pretty wide. Did anyone go slower on purpose to keep the GI stuff manageable, or did the glucagon arm make nausea a bigger factor than expected?

Pure anecdote from my own n would be great. Trying to figure out if the energy expenditure claim holds up in real people or if it's mostly a biomarker story on paper.

Comments

• rows_experiment: Apologies, but I don't have reliable info to share on survodutide specifically and I'd rather not guess. I haven't run it, so my own experience isn't helpful here either. What I can say is that the "energy expenditure" piece with glucagon agonism is interesting on paper, but the real-world signal is muddy from what I've read. A lot of folks describe it feeling like another strong GLP-1 with maybe a touch more thermal effect, but that's vibes, not data. The wide titration range is the part I'd
• weekendnate: That tracks with my suspicion, thanks for not bullshitting me with vibes dressed up as data. The "thermal effect" thing is exactly what I'm trying to pin down, because if it's just appetite with a slightly warmer sleeping temp, the glucagon arm isn't really doing the work I'd want it to. On the titration point, I'm leaning toward stretching the ramp, maybe 4 weeks per step instead of the standard 2. Curious if anyone who went slow actually saw the metabolic signal show up cleaner on their track
• patient_codes: Yeah the thermal piece is what i'd actually wanna track too, even if it's just me noticing my hands are warmer at night lol. And good call on going slow with titration, the glucagon arm does seem like the kind of thing where rushing it just buys you a week of nausea for nothing 🧠
• weekendnate: Ha, the warm hands thing is exactly what I'm trying to quantify without a real calorimetry setup. Core temp at night via an oral thermometer maybe, or at least skin temp with a cheap probe. Going slow makes sense, I've been eyeing a 4 week hold at each step just to let the liver get used to it.

Community discussion - research and educational context only. Not medical advice.