CagriSema vs retatrutide, which one actually feels less rough on the stomach?

Posted by tiredmira in Weight Loss & Metabolic - 1 points, 0 comments.

I've been on tirz for about 8 months now and I'm thinking about switching things up once I hit my goal weight.

Mostly just to see what else is out there at this point.

I've been reading about CagriSema and retatrutide and honestly the weight loss numbers look wild for both.

What I really care about though is the day to day feel, because tirz wipes me out on injection day and the nausea has been pretty consistent even after titrating up slowly.

For anyone who's tried CagriSema specifically, how was the side effect profile for you compared to tirz?

I'm basically wondering if the amylin component makes the nausea worse or if it's actually smoother since it's hitting a different pathway.

And if anyone has experience coming off tirz onto something else, how did that transition go for appetite and energy?

Just trying to get a feel for what the real world experience looks like before I commit 😅

Community discussion - research and educational context only. Not medical advice.