First 4 weeks on AOD-9604: weight, appetite and any sides?

Question

I decided to try AOD-9604 after reading about its lipolysis focus without touching IGF-1 or glucose. I started at the typical 300 mcg subQ each morning fasted, keeping my usual diet and workout routine mostly zone 2 cardio and light lifting. I logged my weight every morning and noted appetite on a simple 1-5 scale. 4 lb per week, nothing dramatic but consistent. My appetite felt a bit lower in the mornings, especially before breakfast, though I’m not sure if that’s the peptide or just the habit of skipping carbs until after the shot. Around week three I noticed mild injection site soreness that faded after a day and occasional light headache mid‑afternoon, nothing that stopped me from working. My HRV stayed flat, no big shifts, and my fasting glucose stayed in the normal range I usually see. 6 lb total. I’m thinking of extending another month to see if the trend picks up or if I hit a true plateau. Has anyone else run a similar length and noticed a delayed effect? Just my own experience, not proof of anything.

chemist_daily · Accepted Answer

I’ve been on AOD‑9604 for about five weeks on a similar 300 µg daily dose, mostly fasted before the injection. My weight dropped roughly 3 lb in the first three weeks, then stalled for a couple of days before ticking down another pound. I also saw a modest dip in my morning hunger rating around a 1‑point drop but only while I kept carbs out of breakfast – when I added a small oatmeal later in the day the appetite boost came right back. The injection site soreness was almost identical for me, and I got a brief, dull head pressure mid‑afternoon once or twice – it cleared up after a glass of water. My HRV and fasting glucose stayed flat, just like yours. I’m planning to push another month and will try a short “off‑week” after six weeks to see if there’s a rebound. Have you thought about tweaking carb timing or adding a light protein shake after the shot to see if it changes the appetite effect? 😅

amber464 · Answer

Thanks for the details, chemistdaily. My headache was more like a light throb than pressure, and I never noticed it bounce back after carbs – I kept oatmeal out entirely. I’ve logged my HRV every morning and it’s still flat, but interestingly my resting pulse dropped about 3 bpm in week 4. I’ll try re‑adding a small carb at lunch next week to see if the appetite dip holds, and will keep tracking the soreness.

First 4 weeks on AOD-9604: weight, appetite and any sides?

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