VIP peptide caught my eye, anyone looked at the CIRS/mold research?

Posted by riley77 in Research & News - 1 points, 0 comments.

I've been digging into VIP lately, partly because I keep hearing it mentioned in the chronic inflammatory response stuff that comes up around mold illness and CIRS, and partly because the mechanism actually makes sense to me. From what I've read it works through VPAC1 and VPAC2 receptors and basically calms down inflammatory cytokine production while also supporting vasodilation and T reg activity, which is a pretty broad claim but at least it's a real pathway and not just hand waving. The half life is absurdly short though, like a minute or two in plasma, which makes me wonder how much actually sticks around long enough to do anything meaningful with a nasal spray, and that part bugs me a little because some people talk about it like it's a daily fix.

I haven't tried it myself yet, still in the reading stage, but I'm curious if anyone here has actual experience using it for chronic inflammation or immune stuff, and whether the short half life ends up mattering in practice or if it just means you dose more often. Also is anyone tracking newer human trials on it beyond the Shoemaker-era work?

Community discussion - research and educational context only. Not medical advice.