Old review on GHRPs and how MK-0677 came from GHRP-6, still useful context

Posted by tyler589 in GH & Growth Peptides - 2 points, 0 comments.

https://www.sciencedirect.com/science/article/abs/pii/S0091302297901588

Saw this older ScienceDirect review on growth hormone-releasing peptides and their analogs. It walks through GHRPs in animals and humans, and traces how the non-peptidyl secretagogues like L-692,429 and MK-0677 were designed using GHRP-6 as a starting template. Good background read if you want to see where the whole GHRP family really started.

For me the interesting part is how MK-677 is basically a pill version of the same idea GHRP-6 was working on decades ago, just tweaked to last longer in the body. The review makes it clear these were developed as legitimate research tools, not gym hacks, which I think gets lost sometimes in forums.

Anyone here still running a GHRP-6 or ipamorelin based stack alongside CJC, and noticing the oral MK-677 research ever since? Curious if the older mechanism still holds up in practice.

Community discussion - research and educational context only. Not medical advice.