New peptide antagonist blocks the GH receptor itself, not just secretion

Posted by midwest_swims in GH & Growth Peptides - 1 points, 0 comments.

https://www.napleslongevity.com/post/growth-hormone-peptides

This one jumped out because most stuff on the board is about turning GH up, but this is about turning GH signalling down at the receptor. The researchers made a small helical peptide that binds the GH receptor and blocks it, and it actually lowered IGF-1 in animal models from what I can gather. The interesting bit for me is that they are framing it as a longer acting alternative to current GH antagonists like pegvisomant, which is a big protein drug and a pain to dose.

My take, if anyone has read it more carefully, does this antagonist look like it actually reduces GH action tissue by tissue, or is it a blunt drop everywhere? Because excess GH in acromegaly is the obvious target, but a reversible receptor blocker could also be useful research wise for studying how much of the body comp effects people chase actually come from the GH signal itself versus IGF-1 downstream.

Anyone here looked into receptor level antagonism at all, or is everyone still focused on the secretagogue side?

Community discussion - research and educational context only. Not medical advice.