Semaglutide titration and HRV crashing, anyone else tracking this?

Posted by emma335 in Weight Loss & Metabolic - 1 points, 0 comments.

So I've been titrating up on semaglutide over the last while and I keep a fairly detailed spreadsheet because I'm that kind of person, tracking HRV, resting heart rate, sleep stages, the whole lot, and I've noticed something a bit odd that I can't fully explain. My HRV drops noticeably for about two to three days after each dose increase before it settles back to baseline, and my deep sleep takes a hit too, like it goes from my usual numbers down a fair bit and I feel it in the mornings even though the appetite suppression is working grand. I'm wondering if it's just the GI stress putting my body under load because I do get a bit of nausea on the higher doses, or if there's something about the GLP-1 pathway itself affecting autonomic tone, but I can't find much out there that maps this out properly.

Has anyone else here been tracking HRV or sleep data while titrating and noticed a similar pattern? I'd be really curious to compare notes because for me it seemed to stabilise after about week three at each dose level but I'd love to hear if that matches what others have seen, or if I'm just reading noise into my own data.

Community discussion - research and educational context only. Not medical advice.