Curious if anyone has tried PE 22-28 or P21 for mood/cognition

Posted by humble_dad in Cognitive & Nootropic - 1 points, 0 comments.

Hey all. I've been digging into some of the less-talked-about cognitive peptides and wanted to see if anyone has hands-on impressions of a couple of them.

First one is PE 22-28. The TREK-1 angle is what caught my attention. I like the idea of something that works on a different pathway than the usual SSRI stuff, and the preclinical neurogenesis data is interesting to me on paper. I have zero human experience with it though, and the safety profile is basically a blank page. Just wondering if anyone has even messed with it for mood or general cognitive feel.

Second is P21. The CNTF-derived piece that skips the appetite suppression sounds clever, and the fact it crosses the BBB is a plus in my book. Again, I haven't pulled the trigger. The limited human data makes me want to hear from someone who has actually tried it.

For me personally, I've had decent responses to the Semax family (Adamax included) for focus days, but I'm always curious about what else is out there that hits neurogenesis without the rough edges.

Anyone here run either of these? Pure anecdote territory for me, just curious what real users have noticed.

Community discussion - research and educational context only. Not medical advice.